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Some preliminary research suggests berberine may indirectly increase endogenous GLP-1 secretion from intestinal cells, but this effect is fundamentally different from directly activating GLP-1 receptors

Tilg, H., Byrne, C

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Interestingly, the researchers found no significant differences between the exenatide and placebo groups in scores of cognitive ability or depression suggesting that the positive effect of exenatide may be specific to the dopamine or motor regions of the brain

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