In our model, depletion of Hypoxia-Inducible Factor 1 alpha (HIF-1) impaired the effects of Exendin-4 on glucose metabolism, while pharmacological inhibition of Phosphoinositide 3-kinase (PI3K) or mTOR completely abolished such effects
1B, Fig
2 However, hormonal therapy causes some severe side effects due to which some of the hormones like methyltestosterone and estrogen are phased out from the market
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