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After 4 weeks, the dose is increased to 0.5 mg per week

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The extrasynaptic tonic current amplitude was quantified as the shift of the baseline current after application of picrotoxin ( Statistics Data were analyzed using GraphPad Prism 10 (GraphPad Software La Jolla, CA, USA)

Variability in response to GH therapy may also be linked to the presence of an exon-3 deletion polymorphism of the GH receptor (d3 allele), which is present in around 50% of the Caucasian population (135)