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STEP-HF (semaglutide in patients with heart failure with preserved ejection fraction and obesity) revealed a large reduction in symptoms and physical limitations in patients who received semaglutide 2.4 mg using the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS)

That said, generally favorable in research is not the same as proven safe for all individuals at all doses a distinction that matters when making clinical decisions

10.1038/srep26859 [DOI] [PMC free article] [PubMed] [Google Scholar] 88.Gerstein HC, Hart R, Colhoun HM, Diaz R, Lakshmanan M, Botros FT, et al

The FDA determined that the semaglutide shortage was resolved on February 21, 2025

The rectum and bladder share close anatomical quarters in the pelvis