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One common nutrient deficiency mentioned previously is B12 deficiency
In addition, a recent study has identified a novel variant (rs143276236) in the gene ARFGEF3 in the discovery cohort with a potential to reduce HbA1c in individuals with metformin monotherapy in African-Americans, although this find was not significant in the validation cohort (Wu et al., 2023)
Tfam can be translocated into mitochondria and binds to mitochondrial mtDNA, with the resultant promotion of both replication and transcription of mtDNA (Parisi and Clayton, 1991
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