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What the broader literature describes is remodeling, not a one-way pile-up

In experimental studies, BPC-157 PEN is analysed primarily in terms of fibroblast activity, cell migration, angiogenesis, endothelial function and extracellular matrix remodelling

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The transcription factors (TF) E2F7 (JASPAR ID: MA0758.1) and E2F8 (JASPAR ID: MA0865.2) can bind to the region encompassing the DML a (chr17: 34283605), while E2F6 (JASPAR ID: MA0471.2) and TFDP1 (JASPAR ID: MA1122.1) can bind to the complementary region of this DML in the minus strand