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10.1038/s41572-023-00454-1 310 MateiB.Winters-StoneK

APOE4/4 is linked to damaging lipid droplets in Alzheimers disease microglia

Glutathion: Helps tissue building and repair, making chemicals and proteins needed in the body, and involves in immune system function

Some patients report increased anxiety, mood changes, sleep disruption, or emotional distress during a Herxheimer reaction

The primary evidence-based interventions remain: Weight loss through caloric restriction and increased physical activity (target 710% body weight reduction) Dietary modification , including reduced sugar and saturated fat intake Management of associated conditions such as diabetes and dyslipidaemia Alcohol : for NAFLD, keep within UK low-risk drinking guidelines (no more than 14 units per week, ideally less or none)