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Adherence is the key problem!If 70% of the patient discontinue the treatment after 6-12 month and regain the weight very quickly, handling the adherence weakness is much more helpful to the patient's health than another 3% weight loss.Alma's smart capsule we can probably load GLP1 or Amylin on a once / twice weekly oral dose

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Glucagon receptor activation causes more gastrointestinal distress than GIP activation, which partly explains why survodutide has higher discontinuation rates in clinical trials compared to tirzepatide

By removing these "scar-forming" cells, it improves tissue architecture and reduces collagen deposition