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Brain Pathol 29(3):351365 el Nashar EM, Obydah W, Alghamdi MA et al (2022) Effects of Stevia rebaudiana Bertoni extracts in the rat model of epilepsy induced by pentylenetetrazol: Sirt-1, at the crossroads between inflammation and apoptosis [J]

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The classic hospital KD protocol involves a 2448-h fast to induce metabolic ketosis, after which the KD ratio is gradually increased, starting with a 1:1 ratio (1 g of fat per 1 g of protein and carbohydrates), until a 4:1 ratio is achieved (61, 64, 65)