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Incretins are gut secreted hormones, G-protein-coupled receptor peptides, that include glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide (GIP) and glucagon (GCG)

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Aside from lifestyle modifications, metformin is considered the first-line treatment for glycemic control according to the 2023 American Association of Clinical Endocrinologys T2DM management algorithm

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J Exp Bot 63(3):13151328