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Downstream effects include concentration-dependent suppression of lipogenesis (50-70% reduction), decreased adipocyte size, and increased basal energy expenditure without appetite suppression

721 Clotrimazole was absorbed from the gastrointestinal tract and had a biological half-life of about 4 hours

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Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length