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Furthermore, enhancing the endometrial metabolic microenvironment and glucose transport may provide a more favorable foundation for early embryonic development and implantation

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Plots on the Supplementary Fig

Targeting specific signaling pathways, such as JAK/STAT, PI3K/AKT, and NF-B, which regulate TAM polarization, along with innovative strategies like nanocarriers, exosomes, and CAR-macrophage therapy, could significantly improve the efficacy of cancer treatments, particularly in solid tumors where immunosuppression is a major challenge (155)

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