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How Semaglutide Works as a GLP-1 Receptor Agonist Semaglutide is a GLP-1 receptor agonist, meaning it mimics the action of glucagon-like peptide-1, a hormone your body naturally produces after eating

At least part of this function is via the recruitment of fibroblasts

The acidic condition of LCIG may alter the chemical situation in the gut, which, finally, leads to hypergrowth of Escherichia/shigella , being acid-tolerant bacteria (Lubomski et al., 2022b)

Preclinical models have shown that GLP-1 analogs suppress hepatic stellate cell activation, the key drivers of fibrogenesis, resulting in reduced collagen deposition and fibrosis (45, 46)

doi: 10.1111/bcpt.v130.2 182 ChenYZhaoYMiaoCYangLWangRChenBet al