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Some drugs are so extensively metabolized on the first pass that they are not effective when given orally and must be administered by an alternative route that bypasses the liver (e.g., sublingual nitroglycerin, IV lidocaine)

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Studies on the possible value of endogenous neurotoxins, oxidative stress markers, inflammatory and immunological markers, and growth and neurotrophic factors as biological markers of PD should be considered as inconclusive

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