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It is also reported that GLP1producing NTS neurons project directly to the VTA and NAc (core and shell) (Alhadeff et al., 2012) and that GLP1 receptor activation of the NTS alters expression of dopaminerelated genes in the VTA (Richard et al., 2015) However, the growing number of brain regions that have shown a positive effect upon GLP1 agonist infusion does not immediately suggest a clear and defined circuitlevel mechanism