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Some patients find semaglutide easier to tolerate long term
Changes in HbA1c in participants with pre-existing pre-diabetes between treatment arms, and in participants with pre-existing T2D between treatment arms, was assessed with the inclusion of an interaction term between diabetes status and treatment allocation in the linear regression model for HbA1c and calculated from estimated marginal means
PubMed 16.Currie CJ, Morgan CL, Poole CD, Sharplin P, Lammert M, McEwan P
step therapy required BCBS of Illinois Covered with PA BMI criteria + documented diet/exercise failure BCBS of Michigan Not covered (fully insured) Removed all GLP-1 weight loss drugs from commercial plans Jan 2025 BCBS of Florida (Florida Blue) Covered with PA BMI 30
Alternating makes more sense when you tolerate each medication for limited periods, when cost and availability force periodic changes, or when a clinician designs a specific cycling protocol for your unique situation
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