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The authors explicitly suggest that therapeutic interventions targeting viral reactivation and inflammationspecifically highlighting powerful antioxidantsare critical for patient recovery

Caspase-3 is involved in the activation cascade in apoptosis, so increased caspase-3 activity can act as a marker for DNA fragmentation and apoptosis in injured and degenerated disc tissue 33

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Interestingly, Gsta4, the main scavenger of the lipid peroxidation product 4-hydroxynonenal (4-HNE), has been predicted to be a target of Nrf2 51,52 , which we corroborated through the observation that both DMF and Clem-F induced the expression of Gsta4 (Fig