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ET-1 has been shown to regulate the expression of LOX-1 through the ET-1 receptor in endothelial cells

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Briefly, when either caspase 8 or fas-associated via death domain (FADD) is depleted or the function is inhibited, TNF can induce caspase 8 independent necrosis through activating RIPK1 (receptor interacting serine/threonine kinase 1) [94]