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In this study, the difference in body weight reduction between tirzepatide- and semaglutide-treated groups can only partly explain the improvement in insulin sensitivity, lending support to the observation that tirzepatide was associated with improvements in insulin sensitivity associated with both body weight-lowering and a potential insulin-sensitizing effects of GIP

In conclusion, increased TMAO levels may be a compensatory mechanism in response to disease

Nearly half reached the 30% threshold, and more than one in four lost at least 35%

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