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In a small number of kindreds, estimated to be fewer than 50 world-wide, a pruritic cutaneous lesion develops invariably over the upper back

These findings indicate glutathione status regulates collagen production through modulation of reactive oxygen species signaling pathways essential for wound repair

Ethical approval The project has been reviewed by the University of Manchester Research Ethics Committee

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Apoptosis, or programmed cell death, is a cellular mechanism that eliminates injured and infected cells or those that have reached the end of their lifespan 75