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Preclinical models found that GLP-1 RAs reduce intestinal inflammation in dextran sulfate sodium (DSS)-induced colitis, by increasing IL-22 production by colonic IELs and several beneficial bacteria, including Firmicutes, Proteobacteria and Lactobacillus reuteri (93)

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Ator2 is located between the S1 and S4 helices, and its dihydroxy heptanoic acid group forms an ionic interaction with Arg4824 in the S4S5 linker

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(2020) Application of methylene blue-vitamin C-N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial