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Polyphenols, in particular, have attracted attention due to their antioxidant, anti-inflammatory, antiproliferative, proapoptotic, and gut-modulating properties 1

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Interestingly, the cuprotosis approach to cell death caused by the tricarboxylic acid cycle is similar to ferroptosis, in that ferroptosis also involves mitochondrial dysfunction and the production of excess acetyl-CoA

The subsequent success of GLP-1 receptor agonists, despite early gastrointestinal intolerance and safety concerns, illustrates how such signals may be manageable through improved formulation and dosing rather than indicative of fundamental biological unsuitability

This astrocyte-neuron lactate shuttle is crucial for maintaining neuronal energy homeostasis when mitochondrial function is impaired (Suzuki et al., 2011