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Bitter vegetables such as chicory, dandelion, radicchio, and artichoke contain sesquiterpene lactones that stimulate bile secretion and activate intestinal TAS2R bitter-taste receptors, generating a combined sensory and hormonal signal that triggers CCK release and colonic reflex activity ( Dietary fats, particularly those rich in monounsaturated and polyunsaturated fatty acids, such as EVOO, nuts, and avocado, further enhance CCK-mediated gallbladder contraction and bile secretion

PMCID: PMC5834427

Resch-Genger, U., Grabolle, M., Cavaliere-Jaricot, S., Nitschke, R

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