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Simultaneously, there are disruptions in the expression of signaling pathways such as Transforming growth factor- (TGF-) signaling pathways, VEGF/VEGFR signaling pathways, Angiopoietin (Ang)/Tie signaling pathways, among others, ultimately driving glomerular fibrosis and progressing towards end-stage pathological conditions like glomerulosclerosis

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Hepatocyte-derived Interleukin-6 and tumor-necrosis factor mediate the lipopolysaccharide-induced acute-phase response and nitric oxide release by cultured rat hepatocytes

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