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Start titration exactly as recommended, because how quickly you escalate matters as much as what you change on the plate: Begin 0.25 mg once weekly for weeks 14 Move to 0.5 mg weekly for weeks 58 Continue gradual increases to your maintenance dose Pair careful titration with targeted, testable adjustments to meals, movement, and simple OTC supports to reduce the risk of severe gas and other GI symptoms as you adapt

But new research focusing specifically on people with bipolar is beginning to provide some answers

This is the single most important safety step in the entire process

Semaglutide works best when taken consistently at the prescribed intervals