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FengQKalariKFridleyBLJenkinsGJiYAboRet al

This has led to conceptualizing obesity as a chronic disease requiring ongoing management rather than a condition amenable to short-term cure

and Paulson, D.J

At the heart of SFNs anti-CSC activity lies its coordinated interference with Wnt/-catenin, Notch, and Hedgehog signaling - three evolutionarily conserved pathways that frequently become dysregulated in CSCs