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25 Among the remaining histamine receptors, H3R is not expressed in the gut mucosa, and H4R is expressed in the gut mucosa by mucosal immune cells 14 (including MCs, eosinophils, T cells, and dendritic cells) as well as nonimmune neuroendocrine cells, enterocytes in the crypt of Lieberkuhn, neurons, and small submucosal blood vessels

They both help increase muscle mass and strength, encourage fat loss, and improve recovery (although clinical trials have mostly been carried out in animal models)