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A 2023 meta-analysis of these trials concluded that probiotics (usually multi-strain combinations of Lactobacillus and Bifidobacterium ) led to a significant reduction in pro-inflammatory cytokines (like TNF- and IL-6) and a slight improvement in patients Expanded Disability Status Scale (EDSS) scores [201]

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We speak with sponsors every day who are tightening criteria or even carving GLP-1s out because the spend feels unsustainable