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Lipid oxidation and oxidative damage to mitochondrial DNA further diminish mitochondrial function, establishing a self-perpetuating vicious cycle to exacerbate mitochondrial dysfunction and oxidative stress [80]
Your body doesnt distinguish between fat and muscle when it needs energy
Similarly, during the dose escalation phase of tirzepatide therapy, when gastrointestinal adverse effects are most common, temporary alcohol avoidance may be prudent until tolerance is established at the maintenance dose
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