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However, the native molecule is rapidly degraded in circulation primarily by the serum enzyme dipeptidyl peptidase-4 (DPP-4), which cleaves at the Tyr-Ala bond at the N-terminus resulting in a biological half-life of just two to seven minutes

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Triple GLP-1 / GIP / Glucagon Receptor Agonist (CAS 2381089-83-2) Compound Name: Research Peptide (CAS 2381089-83-2) Classification: Research Peptide Multi-Receptor Agonist Description: This compound is a synthetic research peptide that functions as a triple agonist of the glucagon receptor (GCGR), glucose dependent insulinotropic polypeptide receptor (GIPR), and glucagon like peptide-1 receptor (GLP-1R)

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Free Radic Biol Med 129:394406