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Regarding exenatide, Trevaskis et al

Due to 150 spontaneous reports to EMA regarding suicidal ideation [5] EMA and FDA have launched independent investigations into the potential risk of suicide and suicide attempts among users of GLP-1 RAs

New medications currently under development are also showing promise for individuals who have not responded well to existing therapies

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MEDI4166 efficiently suppresses PCSK9 and reduces LDL-cholesterol in cynomolgus monkey The effects of MEDI4166 on PCSK9 suppression, LDL-C level and the pharmacokinetic profile based on human GLP-1R activity and Fc detection, to determine in vivo peptide stability, were evaluated in healthy lean cynomolgus monkeys following a single intravenous (iv) dose at 1 or 5 mg/kg or subcutaneous (sc) dose at 10 or 100 mg/kg