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The observation in this study in hepatocytes that protein-SSG formation by either GSSG accumulation or treatment with a direct S -glutathionylation induction agent resulted in IKK--SSG formation, leading to its suppression, was supported by a previous study reporting that S -glutathionylation was associated with suppressed IKK- activity in epithelial cells 41
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10.1093/advances/nmab127 62 TanS.LiuQ.YangJ.CaiJ.YuM.JiY.et al (2022)
Intracellular ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) ranges from 10 to 100
The drug is currently FDA-approved at a dose of 500 mg daily to treat medically refractory, IDH1-mutant acute myeloid leukemia (AML) ( 40 )
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