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Mutations of gene BRAF V600E have been identified in cells derived from the neural crest and large cells containing melanic pigment, which is based on the finding that the oncogenic mutation of BRAF V600E is a fundamental event in the melanotic neoplasia group, often defining diploid tumors and other aneuploids

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Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal

That usually means advanced subjects, plateaued protocols, or longer cycles where metabolic adaptation becomes the limiting factor