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But they are not identical, and one common question is whether tirzepatide is actually better than semaglutide

In nutrient-replete states, GLP-1induced insulin signaling suppresses adipose lipolysis, whereas during reduced caloric intake and relative glucose scarcity, lipid substrates become the dominant oxidative fuel [59, 60]

After 48 weeks, 9 (39%) of the 23 patients who received liraglutide 1.8 mg daily and underwent a follow-up biopsy achieved MASH resolution, compared with only 2 (9%) of 22 patients in the placebo group ( P = .019)

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However, they are not yet FDA-approved