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When medically appropriate, testosterone replacement can complement training and nutrition efforts, particularly during GLP-1-induced weight loss, which can sometimes reduce endogenous testosterone levels due to caloric restriction and fat loss

In support of this, ICV administration of GLP-1 in rats has been shown to attenuate the fasting-induced rise in NPY/AgRP expression and decreases fasting-induced inhibition of POMC/CART expression in the ARC (Seo et al., 2008)

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