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"Since there are no head-to-head trials comparing oral semaglutide for obesity to orforglipron, this indirect treatment comparison from the ORION study provides important information that can be used during the shared decision-making process." Additionally, OPTIC was an online patient preference study assessing key factors driving obesity treatment decisions conducted from October to November 2025
Men with obesity or type 2 diabetes should speak to their GP about currently NICE-approved options such as semaglutide (Wegovy) or tirzepatide (Mounjaro) while trials continue
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