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During the follow-up period, one patient developed hepatocellular carcinoma six years after diagnosis, underwent surgical resection, and is still under follow-up

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POLRMT encodes for the mitochondrial RNA polymerase 26 that plays a critical role in transcription in pancreatic beta-cells and insulin secretion in the pancreas 69

Given the critical role of this cofactor in cell survival, it is likely that NAD + levels are tightly defended by upregulating NAD + biosynthesis, depleting levels of precursors such as NMN (Fig