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According to morphological observations, blue light irradiation can cause congestion and edema of corneal limbal blood vessels, dilation and thinning of the central part of the cornea, protrusion forward, and increased curvature

Similarly, if early dosing causes amplified side effects, you might report that a dose is poorly tolerated when it would have been perfectly fine on a proper 7-day schedule

doi:10.1007/s00106-016-0330-8 Freire AO, Sugai GC, Chrispin FS, et al

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