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When used at normal doses, they complement each other and are safe to combine

Caffeic acid phenethyl ester suppresses proliferation and survival of tw2.6 human oral cancer cells via inhibition of akt signaling

This was supported by the decreased levels of serine in the medium of 1919 cells compared to input media and 2012.2 cells ( p = 0.0129, p = 0.0027, respectively), as well as reduced synthesized serine and glycine into the media (Fig