Sirtuins are known as longevity proteins because of their noteworthy roles in stress resistance, metabolism, apoptosis and aging
The fastest approaches include: reducing dietary histamine intake immediately (avoid aged, fermented, and leftover foods), taking vitamin C, which research shows can support healthy blood histamine levels by up to 38% 26 , using a HEPA air purifier to reduce environmental triggers, and nasal saline irrigation to physically remove irritants

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Gut Microbes 17, 2467193
doi: 10.2337/db22-334-OR 93 Altimmune