The medication works primarily by enhancing glucose-dependent insulin secretion from pancreatic beta cells, meaning insulin release occurs only when blood glucose levels are elevated
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As shown above, our study population was older, had a higher proportion of women, higher HbA1c levels, and higher BMI compared to previous clinical trials comparing semaglutide and dulaglutide
The peptide retains activity in human gastric juice for more than 24 hours, tolerates pH from 1 to 11, and resists multiple proteolytic enzymes, properties that derive from the high proline content (four of fifteen residues) and the absence of cleavage-prone motifs
[18] These trials will provide the robust efficacy and safety data required for a formal regulatory submission