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The only types of GST that are not thought to be found in the cytosol are the theta class, encoded by three genes that direct the proteins to the peroxisome (Dixon et al., Evidence for the importance of the different pathways Biochemical data DHA as oxidant On the basis of modeling of ROS metabolism in the chloroplast, it was suggested that the ascorbate pool could operate largely independently of glutathione because most of the MDHA produced would be efficiently reduced to ascorbate, entailing the formation of little DHA (Polle, 2001)