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(ii) Alpha lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g., vitamins E and C, and reduced glutathione) and has metal-chelating activity

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Gln and GSH have a broad range of functions in the host

For instance, metabolomic analysis of plasma from metformin-treated individuals with high blood glucose levels and those with low blood glucose levels revealed a microbial metabolite, imidazole propionate, as a negative regulator of metformin efficacy in humans (Koh et al., 2020)

It is widely recognized that diabetes affects hippocampal synaptic plasticity, and this disruption in synaptic plasticity is related to cognition