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Glutathione is a natural antioxidant that inhibits the enzyme responsible for pigment formation

Curr Drug Saf 8(2):114119 Chantachaeng W, Chularojanamontri L, Kulthanan K, Jongjarearnprasert K, Dhana N (2011) Cutaneous adverse reactions to sulfonamide antibiotics

Niacinamide (Vitamin B3) strengthens the skin barrier and balances uneven tone

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In very high doses, astaxanthin may cause a slight reddish tint to the skin (similar to eating too many carrots), and glutathione can occasionally cause mild digestive upset if not taken in a liposomal form