Indication : It is used for infertility (after other treatments), prepubertal cryptorchidism, and hypogonadotropic hypogonadism
10.1021/op900059x 56 CohenG.SinetP
Research on GLP-1 receptor agonists demonstrates that appetite suppression, weight loss initiation, and metabolic changes continue progressing throughout weeks two through four at the same dose
It was demonstrated, that metabolic disturbances in hypothalamic astrocytes, caused either by selective knock-out of insulin receptors or decreased generation of reactive oxygen species (ROS) modulated glucose transport via BBB and also led to modification in behavioral responses in experimental animals [95, 96]
Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, et al