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Figure 2 Safety/vital functions None of the monitored values (heart rate, respiratory rate, blood oxygen level, and blood pressure) were outside the normal range, and no respiratory depression, bradycardia, hypotension, or desaturation was observed in any of the subjects

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It is worth noting that, nuclear GSTP inhibited the association between HMGB1 and cPKC and reduced cPKC-mediated HMGB1 phosphorylation through interacting with HMGB1 in response to LPS stimulation