Given that mitochondrial architecture is tightly coupled to bioenergetic capacity, disruption of mitochondrial structural integrity has important consequences for ATP generation and mitochondrialcytoplasmic metabolite exchange [97, 98]
For someone losing 50 lb, this could mean 10-20 lb of muscle tissue lost alongside the fat
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Interactions [edit] Valproate inhibits CYP2C9, glucuronyl transferase, and epoxide hydrolase and is highly protein bound and hence may interact with drugs that are substrates for any of these enzymes or are highly protein bound themselves
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