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10.1016/j.bbrc.2006.08.155

However, most dermatological organisations including the American Academy of Dermatology and the Philippine Dermatological Society, which has monitored this trend closely given its popularity in Asia note that the long-term safety of high-dose glutathione supplementation specifically for cosmetic skin lightening has not been established

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It also converts darker eumelanin into lighter pheomelanin, which naturally shifts the balance toward a brighter complexion