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Extrinsically, dietary long-chain fatty acids (LCFAs) promote Th17 cells and exacerbate the pathogenesis of experimental autoimmune encephalomyelitis (EAE) ( Figure 1 )

Glutathione is present within every cell of the body

Dietitian and/or specialist doctor periodically provided instruction on dietary intake re- cording procedures as part of a behaviour modication program and then later used the subjects food diaries for counselling

Future directions and clinical translation challengestowards mitochondria-guided precision treatment for CRC With a deeper understanding of mitochondrial metabolic reprogramming in CRC, both research and clinical fields are collectively advancing its translation from basic discoveries to precision therapies

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