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The International Hypoglycaemia Study Group (2019) Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management

These findings support the continued development of retatrutide as a potential treatment option for type 2 diabetes, with ongoing phase 3 trials set to further evaluate its efficacy and safety

Impaired Hepatic Function Since impaired hepatic function has been associated with some cases of lactic acidosis, Janumet should generally be avoided in patients with clinical or laboratory evidence of hepatic disease

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Sample size calculation The primary hypothesis is that at the 6-month follow-up, the GLP-1RA group will have a mean FTND score reduction of approximately 2 points compared with the control group